Butalbital, Acetaminophen, and Caffeine (Butalbital Acetaminophen and Caffeine) is a combination prescription medication primarily used to relieve tension headaches and migraines. This medication combines three components: the sedative butalbital, the antipyretic and analgesic acetaminophen, and caffeine, which has vasoconstrictive effects. The synergistic action of these three ingredients effectively alleviates headache symptoms and reduces the dosage of individual components, thereby lowering the risk of side effects.
This medication is typically used for short-term treatment of acute headache attacks. However, due to its mild potential for addiction, physicians strictly limit the duration and dosage of use. Patients should follow medical instructions and avoid long-term or excessive use to prevent dependence or organ damage.
The generic name of this combination drug is "Butalbital, Acetaminophen, and Caffeine." Common brand names in Taiwan and Hong Kong include "Fioricet," among others. Different regions may have different commercial names, but all formulations require a prescription from a healthcare provider for access.
This medication falls under the category of "Combination Headache Treatment Drugs," classified as a combination of "sedatives" and "non-steroidal anti-inflammatory drugs (NSAIDs)." Butalbital is a barbiturate derivative, acetaminophen is an antipyretic and analgesic, and caffeine has vasoconstrictive properties, working together to produce an additive therapeutic effect.
The primary indications are short-term treatment of acute tension headaches and migraines. It is suitable for headaches accompanied by muscle tension, pressure, or pulsatile pain. In specific cases, physicians may prescribe it for headaches with mild anxiety or muscle spasms, but only after evaluating the risk of addiction.
Mild Side Effects:
Serious Side Effects:
Contraindications:
Use during pregnancy requires extreme caution. Especially during the third trimester, it may cause neonatal dependence or respiratory depression. Breastfeeding women should evaluate risks before use, as acetaminophen can pass into breast milk.
Concurrent use with the following substances may enhance side effects:
Avoid consuming caffeine-containing beverages (such as strong tea or coffee) simultaneously, as this may cause increased heart rate or anxiety. Alcohol should be avoided during medication use, as it can potentiate central nervous system depression.
The typical adult dose is 1-2 tablets per dose, taken every 4-6 hours, with a maximum of 4 tablets in 24 hours. Tablets should be swallowed whole and not chewed. Taking with food can reduce gastrointestinal irritation. Physicians will adjust the dose based on age, weight, and condition. Do not increase dose or frequency without medical advice.
Note: This medication is for short-term use only (usually no more than 10 days). Long-term use may lead to tolerance and withdrawal symptoms. Store out of reach of children to prevent accidental ingestion.
If a dose is missed and more than 2 hours remain before the next scheduled dose, take it as soon as possible and adjust the subsequent timing. If close to the next dose, skip the missed dose and resume the normal schedule. Do not double doses to make up for missed ones.
If overdose is suspected, symptoms may include deep coma, slow respiration, vomiting, or seizures. Seek immediate medical attention and bring the medication container. Inform healthcare providers of the dose and timing. Emergency treatments may include gastric lavage, activated charcoal, or respiratory support.
This combination contains acetaminophen, and prolonged or excessive use can cause liver damage, potentially leading to liver failure. It is recommended to strictly follow the physician’s prescribed dosage and frequency, and to undergo regular liver function tests to reduce risk.
What should I do if I experience dizziness or drowsiness after taking this medication?The interaction between butalbital and caffeine may cause dizziness or drowsiness. Avoid driving or operating machinery while symptoms persist. If symptoms continue or worsen, stop medication and consult a healthcare provider to prevent accidents.
What precautions should I take when combining this medication with other painkillers or sedatives?If combined with other acetaminophen-containing or sedative medications (such as sleeping pills), it may increase liver burden or central nervous system depression. Always inform your doctor of all medications you are taking to avoid overdose or adverse interactions.
Is this medication safe for pregnant or breastfeeding women?This combination may pose risks during pregnancy and lactation. Particularly, butalbital may affect fetal development, and acetaminophen can pass into breast milk. Use only if prescribed by a healthcare professional after careful evaluation of risks.
Does alcohol consumption during medication use increase the risk of side effects?Absolutely. Combining alcohol with butalbital enhances central nervous system depression, which can lead to respiratory depression or unconsciousness. Alcohol may also exacerbate liver damage caused by acetaminophen. Alcohol consumption should be strictly avoided during treatment.
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