Lurasidone (brand name Latuda) is a second-generation antipsychotic medication primarily used for the treatment of schizophrenia and manic episodes in bipolar disorder. It works by modulating dopamine and serotonin transmission in the brain, effectively improving symptoms such as hallucinations, delusions, and emotional instability. This medication is formulated as an oral tablet and should be used according to a physician's instructions.
Compared to traditional antipsychotics, Lurasidone has a lower risk of extrapyramidal symptoms and long-term motor side effects but may increase the risk of metabolic abnormalities. Its mechanism of action involves selective antagonism of dopamine D2, serotonin 5-HT7, and 5-HT2A receptors, providing a comprehensive effect on both positive symptoms (such as hallucinations) and negative symptoms (such as emotional flatness).
The generic name is Lurasidone, and the main brand name is Latuda. The medication may have other brand names in different countries, but the generic name remains consistent. Patients should verify that the generic name on the packaging matches the prescription from their healthcare provider.
It belongs to the second-generation antipsychotics (atypical antipsychotics), chemically classified as a dopamine D2/serotonin receptor antagonist. This class of drugs generally offers a better side effect profile relative to benefits, but individual patient assessment is necessary.
Primarily approved for:
In Taiwan, this medication requires a prescription from a healthcare professional and should not be self-adjusted in dosage or treatment duration.
Mild side effects include:
Serious side effects require immediate discontinuation and medical attention:
Contraindications: Patients allergic to Lurasidone or with severe cardiac arrhythmias (such as long QT syndrome) should not use this medication. Prior to use, inform your healthcare provider of any cardiovascular disease history and drug allergies.
Pregnant women or those planning pregnancy should evaluate the risk-benefit ratio, as it may affect fetal development. It is not recommended during breastfeeding, as the drug can be secreted into breast milk.
Contraindicated interactions:
Inform your healthcare provider of any concomitant herbal medicines or dietary supplements, such as St. John’s Wort, which may enhance sedative effects.
The initial dose is usually 20-40 mg daily, adjusted based on efficacy and tolerability, with a maximum dose generally not exceeding 80 mg/day. Tablets should be swallowed whole and not chewed or crushed. Taking the medication at a fixed time, preferably after meals, can reduce gastrointestinal discomfort.
Patients with liver or kidney impairment should reduce the dose; for moderate hepatic impairment, the maximum dose is 40 mg daily. Children and adolescents aged 13-17 are only indicated for bipolar disorder treatment, with doses adjusted according to body weight.
If a dose is missed and more than 6 hours remain before the next scheduled dose, take it as soon as possible. If less than 6 hours remain, skip the missed dose and resume the normal schedule. Do not double the dose to make up for a missed one.
Overdose may cause confusion, muscle rigidity, drowsiness, or arrhythmias. Seek immediate medical attention and bring the medication packaging. The doctor may administer activated charcoal to absorb residual drug or monitor the ECG. Severe overdose may require hospitalization.
Symptoms such as hypotension and respiratory depression should be managed with supportive care, including intubation or intravenous glucose infusion.
It is recommended to take Lurasidone immediately after meals to enhance absorption efficiency. A high-fat meal may increase blood concentration but is not mandatory. Patients should take the medication consistently at the same time and follow their healthcare provider’s instructions regarding dosage and diet.
What should I do if I experience drowsiness or weight gain while taking Lurasidone?Drowsiness is a common initial side effect and usually improves after several weeks. If severe, consult your healthcare provider for possible dose adjustment. Weight gain may be related to metabolic syndrome; regular monitoring of weight and blood glucose levels is advised, along with a low-calorie diet and regular exercise to manage it.
Are there any drug interactions I should be aware of when combining Lurasidone with other psychiatric medications?Using with other dopamine antagonists or anticholinergic drugs may increase side effects such as akathisia or cognitive impairment. Combining with antacids (such as aluminum/magnesium-based) may reduce efficacy; it is recommended to take them at least 2 hours apart. Always inform your healthcare provider of all medications you are using.
What blood tests should be monitored during Lurasidone treatment?Long-term use may affect blood glucose, lipids, and liver function. Metabolic parameters should be monitored every 3-6 months. If there is a history of arrhythmia, the healthcare provider may require ECG monitoring of QT interval. During initial treatment, white blood cell counts should also be checked to exclude hematological abnormalities.
Can I abruptly stop Lurasidone if I want to discontinue?No, abrupt discontinuation is not recommended as it may trigger withdrawal reactions such as anxiety or symptom rebound. Healthcare providers typically develop a gradual tapering plan and closely monitor symptom changes. If intolerable side effects occur, contact your healthcare provider immediately rather than stopping the medication on your own.
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