Treatment of Gallstones

The treatment goals for gallstones are to relieve symptoms, prevent complications, and restore normal life for patients. Treatment strategies are usually based on the size and location of the stones, the severity of symptoms, and the overall health of the patient. Mild symptoms may only require observation and lifestyle adjustments, while patients with acute attacks or recurrent episodes may need surgical or pharmacological intervention.

Modern medicine offers various treatment options, including medication dissolution, endoscopic surgery, and laparoscopic surgery. Physicians will assess the composition of the stones (such as cholesterol stones or pigment stones) to choose the most appropriate plan. Patients need regular follow-ups and should adjust their dietary habits according to physician recommendations to reduce the risk of recurrence.

Current Treatment Options

Treatment for gallstones is divided into two main categories: "symptomatic stones" and "asymptomatic stones." For asymptomatic stones larger than 3 centimeters, physicians may recommend active treatment to avoid future complications. The main treatment methods can be categorized as follows:

  • Watchful waiting: Suitable for asymptomatic small stones, monitored with ultrasound every 6-12 months.
  • Medication therapy: Suitable for patients who cannot undergo surgery or have stones that are amenable to medical treatment.
  • Endoscopic treatment: Used in emergencies for acute obstruction or concurrent pancreatitis.
  • Surgical treatment: For patients with recurrent episodes or concurrent cholecystitis.

Medication Therapy

Medication therapy primarily targets cholesterol stones, but the effect is slower, with a success rate of about 10-30%. Commonly used medications include:

  • Ursodeoxycholic acid (UDCA): Taken orally daily for more than 6 months, may reduce stone size but cannot completely dissolve stones.
  • Pain relievers: Such as non-steroidal anti-inflammatory drugs (NSAIDs) for acute pain control, long-term use should be avoided.
  • Antibiotics: Used only for acute cholecystitis with concurrent infection, common drugs include cephalosporins and fluoroquinolones.

Limitations of medication therapy include long treatment cycles, higher costs, and potential side effects such as liver function abnormalities. Therefore, most medical guidelines recommend medication therapy as a second-line option, suitable only for patients at high risk for surgery.

Non-Pharmacological Therapies

Endoscopic and surgical treatments are direct methods for removing stones, and options can be chosen based on the patient's condition:

Endoscopic Retrograde Cholangiopancreatography (ERCP)

This technique is suitable for stones obstructing the bile duct, where an endoscope is inserted through the mouth into the duodenum to retrieve stones using electrocautery or balloon dilation. The success rate is as high as 80-90%, but it may lead to complications such as pancreatitis or perforation.

Laparoscopic Cholecystectomy

This is currently the most common treatment method, removing the entire gallbladder through 3-4 small incisions. The minimally invasive surgery has a short recovery time, with a complication rate of less than 5%, but patients may experience short-term digestive issues after complete removal.

Extracorporeal Shock Wave Lithotripsy

This method uses high-frequency vibrations to break stones, but its effectiveness is limited and may cause stones to move and obstruct the bile duct. It is currently used mainly for elderly patients who cannot undergo surgery.

Lifestyle Management

Dietary adjustments are an important part of treatment. Patients are advised to:

  • Limit high-fat and high-cholesterol foods (such as fried foods and organ meats).
  • Increase dietary fiber intake (such as whole grains and vegetables).
  • Maintain a moderate weight and avoid rapid weight loss that may trigger stone formation.

Regular exercise can improve bile composition, with a recommendation of 30 minutes of aerobic exercise daily. Avoid working on an empty stomach for long periods, and choose low-fat, high-protein foods during meals to reduce pain caused by excessive gallbladder contractions.

Future Treatment Directions

Current research focuses on developing non-invasive treatments and personalized medicine. Emerging technologies include:

  • Focused ultrasound lithotripsy: Using focused energy to precisely break stones, reducing tissue damage.
  • Gene therapy: Developing targeted drugs for specific causes such as hereditary peroxisomal enzyme deficiencies.
  • Artificial bile acid metabolic regulators: New compounds are being developed to promote stone dissolution.

Clinical trials are also exploring the use of specific probiotics to adjust gut microbiota, which may improve bile composition. However, these technologies are not yet widespread and require rigorous assessment of risks and benefits.

When to Consult a Specialist

Seek immediate medical attention if the following conditions occur:

  • Severe pain in the upper right abdomen accompanied by fever or jaundice.
  • Vomiting with nausea lasting more than 6 hours.
  • Ultrasound shows stones with a diameter greater than 2 centimeters.

High-risk groups with diabetes, obesity, or a family history are advised to undergo ultrasound examinations annually. Physicians may adjust treatment strategies based on the location of the stones (such as in the common bile duct) or the presence of other diseases (such as cirrhosis).

 

Frequently Asked Questions

Do all patients experience digestive problems after undergoing cholecystectomy?

Not all patients will have noticeable symptoms. Some may experience diarrhea or bloating in the early postoperative period, but most will gradually adapt within weeks to months. If symptoms persist severely, it is recommended to consult a physician to assess whether dietary adjustments or medication assistance are needed.

What dietary principles should gallstone patients follow if they choose not to undergo surgery for the time being?

It is advisable to avoid high-fat, high-cholesterol, and high-calorie foods, such as fried items, fatty meats, and full-fat dairy products. Meals can be divided into smaller, more frequent portions, and increasing dietary fiber intake can help reduce the burden on the gallbladder. If symptoms frequently recur, surgical treatment should still be considered.

Is extracorporeal shock wave lithotripsy safe and effective for treating gallstones?

Extracorporeal shock wave lithotripsy may be effective for certain specific types of gallstones, but the success rate is lower than that of cholecystectomy, and it may pose risks of stone obstruction or infection. This method is usually suitable for patients who cannot tolerate surgery or have stones in special locations, and a physician's evaluation is needed to make a decision.

Why do gallstone patients need to take medication for a long time during dissolution therapy?

Medication dissolution therapy requires a long duration (possibly up to several years) to dissolve stones, and it is more effective for cholesterol stones, while pigment stones are usually ineffective. Regular follow-up is necessary during the treatment period, as stones may reform after discontinuation of medication, so it is essential to discuss risks and benefits thoroughly with a physician.

After laparoscopic cholecystectomy, are there any restrictions on exercise or specific positions?

After surgery, it is advisable to avoid vigorous exercise for about 2-4 weeks, but normal daily activities can gradually resume. During the wound recovery period, heavy lifting should be avoided, but moderate walking helps prevent thrombosis. Specific restrictions should be adjusted based on individual recovery and physician instructions.

Gallstones