Understanding Rosacea: Causes, Symptoms, Diagnosis, and Treatment

Rosacea is a common chronic skin condition that primarily affects the central areas of the face, characterized by recurrent redness and vascular dilation. This condition is more prevalent in adults over 30 years old, with a higher proportion of female patients, although male patients may experience more severe symptoms. While it is not life-threatening, the impact on patients' appearance and mental health should not be overlooked.

Modern medical research indicates that the causes of rosacea involve multiple interacting factors, including genetic predisposition, environmental triggers, and immune system abnormalities. Recent clinical statistics show that approximately 16 million people worldwide suffer from this condition, yet more than 50% of patients remain undiagnosed. This article will comprehensively analyze this common dermatological condition, covering its causes, symptoms, diagnosis, and treatment options.

Causes and Risk Factors

The exact mechanism of rosacea is not fully understood, but several key factors have been identified by the medical community. Genetic studies show that if someone in the family has this condition, the risk for offspring increases by 2-3 times. Abnormal skin barrier function is also a significant cause; a decreased ability of the stratum corneum to retain moisture makes the skin more susceptible to external irritants. Additionally, the overgrowth of specific microorganisms, such as Staphylococcus epidermidis, may trigger chronic inflammatory responses.

Environmental triggers play a crucial role in the onset of the disease, including:

  • UV exposure: Prolonged sun exposure can exacerbate redness.
  • Temperature changes: Extreme heat or cold can provoke symptoms.
  • Chemical irritants: Cosmetics containing alcohol or fragrances.
  • Dietary factors: Spicy foods and high histamine foods (such as cheese and pickled items).

Abnormal immune system activity is also a key mechanism, with overactivation of T lymphocytes leading to persistent vascular dilation. Recent studies have found an abnormal increase in the number of Demodex mites in the sebaceous glands, which may be associated with symptom exacerbation.

Symptoms

The symptoms of rosacea can be divided into core symptoms and subtype manifestations. Common early symptoms during the "flushing phase" include:

  • Temporary flushing in the central facial area, worsening with touch or temperature changes.
  • Visible capillary dilation resulting in permanent erythema.
  • Increased sensitivity of the skin to hot drinks, hot foods, or emotional stress.

As the condition progresses, different subtype manifestations may appear:

  • Papulopustular type: Red papules and pustules appear, resembling acne but without blackheads.
  • Ocular symptoms type: Eyelid swelling, dry eyes, or a sandy sensation.
  • Rhinophyma type: Tissue overgrowth of the nose forming a nasal tumor, more common in male patients.

The severity of symptoms is closely related to lifestyle, with patients often experiencing acute flare-ups triggered by stress, alcohol consumption, or specific foods. Notably, about 30% of patients may also exhibit ocular symptoms, requiring joint treatment from dermatology and ophthalmology.

Diagnosis

Diagnosing rosacea primarily relies on clinical presentation, but it is essential to rule out similar conditions such as common acne or seborrheic dermatitis. Dermatologists typically begin with a visual examination, observing the symmetry of erythema in the three facial zones (forehead, cheeks, and nose). The recently developed "rosacea diagnostic criteria" categorizes symptoms into core and secondary symptoms, with core symptoms requiring the presence of persistent erythema and flushing triggered by specific factors.

The diagnostic process may include:

  1. Detailed medical history inquiry: Documenting the duration of symptoms and triggering factors.
  2. Dermatoscopic examination: Observing capillary dilation and changes in skin thickness.
  3. Ruling out other diseases: Such as systemic lupus erythematosus or contact dermatitis.

In special cases, a skin biopsy may be performed to exclude other chronic skin lesions. The accuracy of diagnosis is closely related to the experience of the physician, and it is recommended to seek treatment from specialized dermatological medical institutions.

Treatment Options

Treatment strategies should be tailored to the severity of symptoms, with mild patients often benefiting from topical medications. Topical treatments include:

  • Antibiotic ointments: Such as metronidazole or itraconazole.
  • Retinoids: To improve keratin metabolism and reduce inflammation.
  • Anti-inflammatory medications: Such as clindamycin gel.

Moderate to severe symptoms may require oral medication treatment, with common regimens including:

  • Oral antibiotics: Such as tetracycline antibiotics, with attention to resistance issues.
  • Anti-inflammatory drugs: Such as isopropamide to alleviate acute flare-ups.
  • Laser treatment: Pulsed dye laser can improve vascular dilation.

Emerging treatment technologies like photodynamic therapy, which combines specific medications with specific wavelength light sources, can precisely eliminate inflammatory cells. Treatment plans should be accompanied by daily skin care, with physicians typically recommending the use of non-irritating skincare products and strict avoidance of triggering factors.

Prevention

While it is impossible to completely prevent rosacea, daily care can reduce the frequency of flare-ups. In terms of skin care, it is recommended to use fragrance-free, low-irritation cleansing products, and daily care steps should not exceed three times. When going out, sunscreen products with SPF 30 or higher should be used, along with physical barriers (such as wide-brimmed hats).

Lifestyle adjustments are crucial for controlling the condition:

  • Avoid high-temperature environments: Such as hot foods, hot water washing, and saunas.
  • Diet management: Reduce spicy foods and alcohol, especially red wine.
  • Emotional management: Stress management courses or mindfulness practices can reduce the frequency of flare-ups.
  • Cosmetic selection: Avoid products containing alcohol or fruit acids.

Regular skin check-ups can help detect changes in symptoms early, with recommendations for professional skin assessments every 3-6 months. Patients should maintain a personalized trigger diary to assist physicians in adjusting treatment plans.

When to See a Doctor?

If persistent flushing of unknown cause appears on the face and lasts for more than six weeks, prompt medical attention should be sought. If symptoms affect daily social activities or if the following warning signs occur, immediate medical consultation is necessary:

  • Expansion of erythema to the ears or neck.
  • Presence of painful nodules or pustules.
  • Ocular symptoms causing blurred vision.
  • Decreased effectiveness of current treatment plans.

It is advisable to use the "Rosacea Severity Assessment Scale" for self-evaluation, and when the total score exceeds 8 points, a professional diagnosis should be arranged. Regular follow-up treatment can effectively control the condition and prevent progression to the late stage of nasal tissue overgrowth.

 

Frequently Asked Questions

How to distinguish rosacea from general facial flushing?

Facial flushing in rosacea typically lasts longer (over 10 minutes) and may be accompanied by telangiectasia or papules. If flushing occurs briefly in response to hot or cold environments or dietary triggers without skin damage, it may be a temporary reaction. It is advisable to observe whether persistent erythema or pus bumps accompany it; if in doubt, consult a dermatologist for diagnosis.

Which ingredients in daily skincare products may trigger rosacea exacerbation?

Irritating ingredients such as alcohol, fruit acids, and salicylic acid may worsen symptoms. It is recommended to choose fragrance-free, alcohol-free low-sensitivity formulations and prioritize products labeled "rosacea-friendly" or "suitable for sensitive skin." New products should be patch tested on a small area and monitored for 24-48 hours for any adverse reactions.

What are the indications and potential risks of oral medication treatment for rosacea?

Oral antibiotics (such as tetracycline) or pulsed therapy may be used for moderate to severe cases when topical medications are insufficient. Long-term use of antibiotics may lead to gut microbiome imbalance or resistance, requiring regular evaluation as per medical advice. In severe cases, immunomodulators may be used, but potential risks such as liver and kidney function should be assessed.

What dietary restrictions or recommendations should rosacea patients be aware of?

Spicy foods, alcohol, and high-calorie diets may trigger redness, so it is advisable to reduce intake. A mild diet combined with antioxidant-rich fruits and vegetables (such as blueberries and leafy greens) may help alleviate symptoms. Research shows that caffeine has a wide range of individual responses, and some patients may need to avoid it; adjustments should be based on personal symptom reactions.

How effective is laser treatment for rosacea-related telangiectasia? What precautions should be taken?

Pulsed light or 595nm dye laser can significantly improve telangiectasia, with treatment typically requiring 3-6 sessions, spaced 4-6 weeks apart. Strict sun protection and avoidance of irritating skincare products are necessary post-treatment; mild swelling may occur initially, and severe cases may require accompanying medication. Prior to the procedure, patients should inform the physician of their medical history, especially if there is a history of aneurysms that requires careful evaluation.

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