Treatment of Rosacea

The treatment goals for rosacea are to alleviate redness and swelling, reduce skin inflammation, and prevent symptom worsening. Treatment strategies should be tailored based on the severity of the patient's symptoms, skin type, and lifestyle, typically combining both pharmacological and non-pharmacological methods. Physicians will adjust the treatment plan according to individual needs to achieve long-term control.

The treatment process requires close cooperation between the patient and the healthcare team, with regular follow-ups and adjustments to medication. Current treatment methods include pharmacotherapy, physical therapy, and lifestyle adjustments, employing a multifaceted approach to enhance treatment efficacy.

Current Treatment Options

Modern medicine offers various treatment options, primarily categorized into pharmacological treatment, physical therapy, and lifestyle management. Pharmacological treatment mainly involves anti-inflammatory medications, supplemented by topical or oral medications to control symptoms. Physical therapies such as laser or light therapy can improve vascular dilation and erythema, while lifestyle adjustments can reduce triggers and slow disease progression.

For patients with prominent vascularity, Pulsed Dye Laser (PDL) can selectively destroy dilated blood vessels, shortening the treatment cycle. Severe edema cases may require oral immunomodulators, but strict monitoring for side effects is necessary. Recent studies have also developed a "dual therapy" combining medications and lasers to enhance skin barrier repair.

Pharmacological Treatment

Topical Medications

Topical antibiotics such as Metronidazole Gel are the first-line choice, as their antibacterial and anti-inflammatory effects can alleviate redness and papules. 1% Ivermectin Gel targets the hypothesis of small mites, suitable for patients resistant to antibiotics. Topical retinoids (like Adapalene Gel) can promote keratin metabolism, but caution is needed as they may cause initial irritation.

  • Metronidazole Gel: Apply 1-2 times daily, continuous use for several weeks is required to see results.
  • Ivermectin Gel: Use 3 times a week, avoiding contact with the delicate skin around the eyes.
  • 0.75% Azelaic Acid Gel: Shows significant improvement for telangiectasia.

Oral Medications

Oral antibiotics such as Doxycycline or Minocycline effectively suppress inflammatory responses. It is recommended to use them at low doses for long-term to avoid resistance. Severe inflammatory cases may use oral corticosteroids, but only for short-term use to minimize side effects.

New biological agents such as anti-IL-17 monoclonal antibodies are currently in clinical trials and are expected to provide new options for refractory rosacea. Physicians will develop individualized medication plans based on the extent of skin damage.

Non-Pharmacological Therapy

Light Therapy and Laser Treatment

Pulsed Dye Laser (PDL) specifically targets erythema and vascular dilation, contracting blood vessels through selective photothermal effects. Intense Pulsed Light (IPL) can simultaneously improve various skin issues, but multiple treatments are needed to achieve optimal results. The 1,064nm laser is suitable for deep vascular repair, especially for dilated blood vessels in the neck.

  • After laser treatment, enhance moisturizing and sun protection to avoid rebound.
  • IPL treatment intervals are recommended every 4-6 weeks, with a total of 3-5 sessions per treatment course.

Surgical and Aesthetic Treatments

Severe nasal tissue hypertrophy (rhinophyma) may require minimally invasive surgical correction. Microneedling can promote collagen regeneration and improve skin texture. Ingredients such as niacinamide and ceramides in medical-grade skincare products can strengthen skin barrier function and reduce the recurrence of symptoms.

Lifestyle Management

Daily skincare is an important aspect of treatment. Gentle cleansing steps avoid damaging the skin barrier, and it is recommended to use soap-free cleansers. A sun protection factor of at least SPF 30 is advised, with reapplication to block UV triggers.

  • Avoid high-temperature environments: Hot foods, saunas may trigger flushing.
  • Dietary adjustments: Reduce intake of spicy foods, alcohol, and fermented products.
  • Emotional management: Stress regulation can alleviate symptoms through mindfulness training or regular exercise.

Future Treatment Directions

Gene therapy and microbiome modulation are research hotspots, attempting to block disease progression from inflammatory signaling pathways. Biological agents targeting excessive activation of Th17 cells are currently in clinical trials and may become a third-line treatment option.

With the trend towards personalized medicine, genetic testing will assist physicians in predicting drug responses and formulating more precise treatment plans. The development of new anti-inflammatory drugs focuses on JAK-STAT pathway inhibitors, which are expected to reduce the frequency of traditional antibiotic use.

When to Consult a Specialist

When symptoms affect daily life, such as persistent redness or new skin lesions, immediate medical evaluation is necessary. If symptoms worsen after self-medication or if papulopustular lesions appear, a dermatologist should perform a classification diagnosis. Before undergoing new medications or laser treatments, it is essential to discuss risks and benefits with the physician.

When eye symptoms such as conjunctivitis or corneal ulcers occur, referral to an ophthalmologist is necessary in addition to dermatology consultation. If treatment effects are not significant, it may be necessary to reassess the medication cycle or adjust combination therapy, making professional evaluation crucial.

 

Frequently Asked Questions

How to identify and avoid triggers for rosacea?

Triggers for rosacea include changes in environmental temperature, spicy foods, alcohol, stress, hot foods, or hot drinks. Patients can keep a diary to record the correlation between symptoms and daily activities, gradually eliminating behaviors that may trigger redness or inflammation, and avoiding known irritants.

What factors should be considered when choosing topical ointments or oral medications for treatment?

Treatment choices depend on the severity of skin symptoms, the affected areas (such as central facial redness or papules), and the patient's tolerance to medications. Mild symptoms may first try topical antibiotics or vasoconstrictors; moderate to severe or recurrent cases may require oral antibiotics or isotretinoin. It is recommended to decide after evaluation by a dermatologist.

Should daily skincare routines be adjusted during treatment?

During treatment, it is advisable to use fragrance-free, low-irritation skincare products, avoiding those containing alcohol or alpha hydroxy acids. It is recommended to choose soothing and repairing moisturizing products and to avoid vigorous massaging or rubbing of the skin to prevent exacerbating vascular dilation or inflammation.

What is the impact of ultraviolet rays on rosacea? How to protect against it?

Ultraviolet rays can exacerbate skin redness and capillary dilation; it is recommended to use broad-spectrum sunscreen (such as zinc oxide) daily, along with physical barriers like umbrellas and wide-brimmed hats. When using oral medications (like isotretinoin) during treatment, special attention should be paid to the risk of photosensitivity and to avoid sun exposure.

Can rosacea be transmitted to others through contact?

Rosacea is not an infectious disease; its causes are related to abnormal capillary dilation, specific skin microbiome imbalances (such as Demodex), or immune responses, and it is not transmitted through contact or air. However, patients may experience symptom exacerbation due to psychological stress, so emotional management is important.

Rosacea